Mutations to ribosomal components can result in rare diseases known as ribosomopathies. These diseases manifest as anemia, bone marrow failure, craniofacial deformities, triphalangeal thumb, and an increased predisposition to cancer. In the Girodat lab, we are actively investigating how mutations to these ribosomal components (i.e., S19, L11, and L5) disrupt the structure-function relationship of the ribosome. We are using structural methodologies such as cryo-EM and molecular dynamics simulations to understand how these mutations alter ribosomal structure. Additionally, we use in vitro and in vivo approaches to understand how these disruptions affect the translational output of ribosomes.